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41.
Relations between subexponential densities and locally subexponential distributions are discussed. It is shown that the class of subexponential densities is neither closed under convolution roots nor closed under asymptotic equivalence. A remark is given on the closure under convolution roots for the class of convolution equivalent distributions. 相似文献
42.
Non-negative matrix factorization (NMF) is a technique of multivariate analysis used to approximate a given matrix containing non-negative data using two non-negative factor matrices that has been applied to a number of fields. However, when a matrix containing non-negative data has many zeroes, NMF encounters an approximation difficulty. This zero-inflated situation occurs often when a data matrix is given as count data, and becomes more challenging with matrices of increasing size. To solve this problem, we propose a new NMF model for zero-inflated non-negative matrices. Our model is based on the zero-inflated Tweedie distribution. The Tweedie distribution is a generalization of the normal, the Poisson, and the gamma distributions, and differs from each of the other distributions in the degree of robustness of its estimated parameters. In this paper, we show through numerical examples that the proposed model is superior to the basic NMF model in terms of approximation of zero-inflated data. Furthermore, we show the differences between the estimated basis vectors found using the basic and the proposed NMF models for \(\beta \) divergence by applying it to real purchasing data. 相似文献
43.
Desmosine is a crosslinking pyridinium amino acid of elastin, which is a useful biomarker for the diagnosis of chronic obstructive pulmonary disease (COPD) by LC–MS/MS analysis. We previously reported a synthesis of desmosine-d4, which is useful as an internal standard for quantitative LC–MS/MS analysis of desmosines, by deuterogenation of an alkyne group; however, the isotopic purity of the desmosine-d4 was only ca. 50%. The present report describes a new synthesis of desmosine-d4 that improves the isotopic purity to ca. 90% by exchanging the protons of the amino groups to deuterium using deuterogenation. 相似文献
44.
Tsukiho Hayashi Ayumi Osawa Takehiro Watanabe Yoshiko Murata Atsushi Nakayama Kosuke Namba 《Tetrahedron letters》2017,58(20):1961-1964
1,3a,6a-Triazapentalene (TAP)-labeled enterobactin was developed as an iron ion sensor. 3-Acetylated-TAP was successfully introduced to the catechol ring of enterobactin, a well-recognized siderophore secreted by various Gram-negative bacteria. The fluorescence of TAP-labeled enterobactin decreased gradually as the amount of Fe3+ ion as an additive was increased, and 1.2 equiv of Fe3+ ion completely quenched the fluorescence. In clear contrast, when other metal ions were used, the fluorescence of TAP-labeled enterobactin remained even at 5.0 equiv. 相似文献
45.
Takahiro Matsumoto Seikou Nakamura Naoto Kojima Tomohiro Hasei Masayuki Yamashita Tetsushi Watanabe Hisashi Matsuda 《Tetrahedron letters》2017,58(36):3574-3578
From the methanolic extract of the aerial parts of Isodon japonicus, two new ent-kaurane diterpenes, isodonterpenes I and II, were isolated together with 10 known diterpenes. Their chemical structures were elucidated on the basis of chemical and physicochemical evidence. The absolute configuration of isodonterpene I was elucidated by Cu-Kα X-ray crystallographic analysis. Antimutagenic activities of the major diterpenes were evaluated by the Ames test. This study represents the first evaluation of the antimutagenic activities of ent-kaurane diterpenes. 相似文献
46.
Yuya Ikeuchi Dr. Hiroshi Takatsu Dr. Cédric Tassel Yoshihiro Goto Taito Murakami Prof. Hiroshi Kageyama 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(21):5864-5867
A high-pressure reaction yielded the fully occupied tetragonal tungsten bronze K3W5O15 (K0.6WO3). The terminal phase shows an unusual transport property featuring slightly negative temperature-dependence in resistivity (dρ/dT<0) and a large Wilson ratio of RW=3.2. Such anomalous metallic behavior possibly arises from the low-dimensional electronic structure with a van Hove singularity at the Fermi level and/or from enhanced magnetic fluctuations by geometrical frustration of the tungsten sublattice. The asymmetric nature of the tetragonal tungsten bronze KxWO3-K0.6−yBayWO3 phase diagram implies that superconductivity for x≤0.45 originates from the lattice instability because of potassium deficiency. A cubic perovskite KWO3 phase was also identified as a line phase—in marked contrast to NaxWO3 and LixWO3 with varying quantities of x (<1). This study presents a versatile method by which the solubility limit of tungsten bronze oxides can be extended. 相似文献
47.
Keigo Kobayashi Prof. Hirokazu Kobayashi Prof. Mitsuhiko Maesato Dr. Mikihiro Hayashi Tomokazu Yamamoto Dr. Satoru Yoshioka Prof. Syo Matsumura Prof. Takeharu Sugiyama Dr. Shogo Kawaguchi Prof. Yoshiki Kubota Prof. Hiroshi Nakanishi Prof. Hiroshi Kitagawa 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(23):6678-6682
We report on hexagonal close-packed (hcp) palladium (Pd)–boron (B) nanocrystals (NCs) by heavy B doping into face-centered cubic (fcc) Pd NCs. Scanning transmission electron microscopy–electron energy loss spectroscopy and synchrotron powder X-ray diffraction measurements demonstrated that the B atoms are homogeneously distributed inside the hcp Pd lattice. The large paramagnetic susceptibility of Pd is significantly suppressed in Pd–B NCs in good agreement with the reduction of density of states at Fermi energy suggested by X-ray absorption near-edge structure and theoretical calculations. 相似文献
48.
Effect of Acid Treatment of Montmorillonite on “Support‐Activator” Performance to Support Metallocene for Propylene Polymerization Catalyst 下载免费PDF全文
Takao Tayano Hideshi Uchino Takehiro Sagae Katsuyuki Yokomizo Koji Nakayama Shigeki Ohta Hiroshi Nakano Masahide Murata 《大分子反应工程》2017,11(2)
This work is focused on montmorillonite (MMT)‐based “support‐activators” (S‐As) for the metallocene‐catalyzed propylene polymerization. This catalyst was previously industrialized; however, for further technological advances, the activation mechanism is investigated. The chemical and morphological requirements of the S‐A are surveyed using both commercially available raw clay minerals (non‐acid‐treated) and acid‐treated clay minerals. The S‐A possessing strong‐acid sites (pK a < ?8.2) gives a highly active catalyst. Acid treatment of MMT induces morphological changes as well as the formation of strong acid sites. Based on pore size distribution analysis and atomic force microscopy observations, it is concluded that the strong acid sites are located in the small pores around the edge of the clay mineral (not in the interlayer), where the structure is disordered by the acid treatment.
49.
Jeferson Rodrigo Souza Pina Joo Victor Silva-Silva Josiwander Miranda Carvalho Heriberto Rodrigues Bitencourt Luciano Almeida Watanabe Juan Matheus Pereira Fernandes Guilherme Eduardo de Souza Anna Caroline Campos Aguiar Rafael Victorio Carvalho Guido Fernando Almeida-Souza Ktia da Silva Calabrese Patrícia Santana Barbosa Marinho Andrey Moacir do Rosario Marinho 《Molecules (Basel, Switzerland)》2021,26(11)
The natural compound ravenelin was isolated from the biomass extracts of Exserohilum rostratum fungus, and its antimicrobial, antiplasmodial, and trypanocidal activities were evaluated. Ravenelin was isolated by column chromatography and HPLC and identified by NMR and MS. The susceptibility of Gram-positive and Gram-negative bacteria strains to ravenelin was determined by microbroth dilution assay. Cytotoxicity was evaluated in hepatocarcinoma cells (HepG2) and BALB/c peritoneal macrophages by using MTT. SYBR Green I-based assay was used in the asexual stages of Plasmodium falciparum. Trypanocidal activity was tested against the epimastigote and intracellular amastigote forms of Trypanosoma cruzi. Ravenelin was active against Gram-positive bacteria strains, with emphasis on Bacillus subtilis (MIC value of 7.5 µM). Ravenelin’s antiparasitic activities were assessed against both the epimastigote (IC50 value of 5 ± 1 µM) and the intracellular amastigote forms of T. cruzi (IC50 value of 9 ± 2 µM), as well as against P. falciparum (IC50 value of 3.4 ± 0.4 µM). Ravenelin showed low cytotoxic effects on both HepG2 (CC50 > 50 µM) and peritoneal macrophage (CC50 = 185 ± 1 µM) cells with attractive selectivity for the parasites (SI values > 15). These findings indicate that ravenelin is a natural compound with both antibacterial and antiparasitic activities, and considerable selectivity indexes. Therefore, ravenelin is an attractive candidate for hit-to-lead development. 相似文献
50.
Dr. Neil J. Stewart Hitomi Nakano Shuto Sugai Mitsushi Tomohiro Yuki Kase Yoshiki Uchio Dr. Toru Yamaguchi Yujirou Matsuo Dr. Tatsuya Naganuma Dr. Norihiko Takeda Dr. Ikuya Nishimura Dr. Hiroshi Hirata Dr. Takuya Hashimoto Dr. Shingo Matsumoto 《Chemphyschem》2021,22(10):915-923
Hyperpolarized [1-13C]fumarate is a promising magnetic resonance imaging (MRI) biomarker for cellular necrosis, which plays an important role in various disease and cancerous pathological processes. To demonstrate the feasibility of MRI of [1-13C]fumarate metabolism using parahydrogen-induced polarization (PHIP), a low-cost alternative to dissolution dynamic nuclear polarization (dDNP), a cost-effective and high-yield synthetic pathway of hydrogenation precursor [1-13C]acetylenedicarboxylate (ADC) was developed. The trans-selectivity of the hydrogenation reaction of ADC using a ruthenium-based catalyst was elucidated employing density functional theory (DFT) simulations. A simple PHIP set-up was used to generate hyperpolarized [1-13C]fumarate at sufficient 13C polarization for ex vivo detection of hyperpolarized 13C malate metabolized from fumarate in murine liver tissue homogenates, and in vivo 13C MR spectroscopy and imaging in a murine model of acetaminophen-induced hepatitis. 相似文献